D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications
نویسندگان
چکیده
منابع مشابه
The Effect of Preanalytical, Analytical, and Postanalytical Variables on D-dimer Measurement
D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the uoptimal duration of anticoa...
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When a new D-dimer method is evaluated it is typically compared to an established D-dimer method. Usually both an analytical and a clinical comparison are made. The range of clinical specificities between D-dimer assays is wide (from 30 % to above 90 %), which is due to heterogeneity between D-dimer molecules and difference between antibody specificity towards them, especially concerning the pr...
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ژورنال
عنوان ژورنال: Critical Reviews in Clinical Laboratory Sciences
سال: 2018
ISSN: 1040-8363,1549-781X
DOI: 10.1080/10408363.2018.1529734